Tetrahedron letters

β-Alkoxyvinyl trichloromethyl ketones as N-heterocyclic acylating agent. A new access to 5H-thiazolo [3, 2-a] pyrimidin-5-ones

…, RV Lourega, AD Wastowski, AFC Flores, N Zanatta…

Index: Bonacorso, Helio G; Lourega, Rogerio V; Wastowski, Arci D; Flores, Alex F.C; Zanatta, Nilo; Martins, Marcos A.P Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9315 - 9318

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Citation Number: 43

Abstract

Using trichloromethyl substituent as convenient leaving group for the synthesis of interesting bi-heterocyclic compounds, a series of 6-methyl-and 7-alkyl (aryl)-5H-thiazolo [3, 2-a] pyrimidin-5-ones, where alkyl= methyl, n-propyl, isopropyl, isobutyl, n-hexyl, isopentyl and aryl= phenyl, 4-toluyl, 4-chlorophenyl, 4-bromophenyl, 4-methoxyphenyl was obtained from a simple and regiospecific reaction of 4-alkoxy-1, 1, 1-trichloro-3-alken-2-ones with 2- ...