Journal of medicinal chemistry

Synthesis of aminomethyl-substituted cyclic imide derivatives for evaluation as anticonvulsants

ES Stratford, RW Curley Jr

Index: Stratford, Eugene S.; Curley, Robert W. Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1463 - 1469

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Citation Number: 25

Abstract

A series of aminomethyl-substituted cyclic imides (11) based on the 2, 5-pyrrolidinedione (X= CHP, succinimide) and 2, 44midazolidinedione (X= NH, hydantoin) ring systems have been prepared. The compounds were designed on the basis of a potential interaction in the y-aminobutyric acid (GABA) neurotransmitter system and evaluated for anticonvulsant activity. The 3-(aminomethyl)-2, 5-pyrrolidinediones were prepared by a dehydration ...