Chemistry of Substituted Quinolines: Thieno [2, 3-b] and Thiopyrano [2, 3-b] quinolines

…, BP Nandeshwarappa, VP Vaidya…

Index: Kiran, Balaji M.; Nandeshwarappa, Belalakatte P.; Vaidya, Vijayavittala P.; Mahadevan, Kittappa M. Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 5 p. 969 - 980

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Citation Number: 9

Abstract

The reaction of 3-formyl-2-chloroquinolines with thioglycolic acid afforded a mixture of uncyclized [(3-formylquinolin-2-yl) thio] acetic acid in a 60–70% yield and cyclized thieno [2, 3-b] quinoline-2-carboxylic acids in a 30–40% yield, respectively. The uncyclized compounds on refluxing with POCl 3 in various alcoholic media gave [(3-formylquinolin-2-yl) thio] acetates. Further cyclization was achieved by refluxing them with dimethylformamide ...