Ionic Acylating Agents for the Enzymatic Resolution of sec??Alcohols in Ionic Liquids

NMT Lourenço, CM Monteiro…

Index: Lourenco, Nuno M. T.; Monteiro, Carlos M.; Afonso, Carlos A. M. European Journal of Organic Chemistry, 2010 , # 36 p. 6938 - 6943

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Citation Number: 6

Abstract

Abstract Potential acylating agents containing pendant ionic groups have been screened for the enzymatic kinetic resolution of rac-secondary alcohols in ionic liquids with CAL-B as biocatalyst. This study has allowed the identification of the 1-methyl-3-alkylimidazolium cation attached to a carboxylate group through a C 10-alkyl chain as an efficient acylating agent for this transformation. This strategy was applied to the resolution of 2- ...