Synthesis of methyl 2-oxo-5-vinyl-2, 5-tetrahydrofuran-3-carboxylate
MA Silvestri, C He, A Khoram, SD Lepore
Index: Silvestri, Maximilian A.; He, Chang; Khoram, Anita; Lepore, Salvatore D. Tetrahedron Letters, 2006 , vol. 47, # 10 p. 1625 - 1626
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Citation Number: 7
Abstract
As part of an ongoing total synthesis project, we required a reliable and scaleable procedure for the preparation of methyl 2-oxo-5-vinyl-tetrahydrofuran-3-carboxylate (1a). 1 Initial attempts to prepare 1a centered on a reported one-step procedure for the synthesis of ethyl ester analog 1b involving the condensation of diethyl malonate with butadiene monoxide. 2 However, repeated attempts to condense malonate ester with butadiene monoxide following the reported ...
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