Rational Design of a Solvatochromic Fluorescent Uracil Analogue with a Dual??Band Ratiometric Response Based on 3??Hydroxychromone

…, BY Michel, AS Klymchenko, R Benhida…

Index: Dziuba, Dmytro; Karpenko, Iuliia A.; Barthes, Nicolas P. F.; Michel, Benoit Y.; Klymchenko, Andrey S.; Benhida, Rachid; Demchenko, Alexander P.; Mely, Yves; Burger, Alain Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 1998 - 2009

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Citation Number: 22

Abstract

Abstract Fluorescent nucleoside analogues with strong and informative responses to their local environment are in urgent need for DNA research. In this work, the design, synthesis and investigation of a new solvatochromic ratiometric fluorophore compiled from 3- hydroxychromones (3HCs) and uracil fragments are reported. 3HC dyes are a class of multi- parametric, environment-sensitive fluorophores providing a ratiometric response due to ...