Chemical communications

An iterative route to “decorated” ethylene glycol-based linkers

G Lu, S Lam, K Burgess

Index: Lu, Genliang; Lam, Sang; Burgess, Kevin Chemical Communications, 2006 , # 15 p. 1652 - 1654

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Citation Number: 42

Abstract

Oligomeric compounds of a perfectly defined length, polydispersity 1.0, are highly desirable for a variety of applications. We were interested in using them to link peptidomimetics providing bi- and multivalent molecules that might potentially bind with protein targets. 1 We needed linkers with some intrinsic water solubility, that did not have charged functional groups, but that were able to span dimensions from about 10 Å to around 50 Å. They might also incorporate ...