Caged phospho-amino acid building blocks for solid-phase peptide synthesis
DM Rothman, ME Vazquez, EM Vogel…
Index: Rothman, Deborah M.; Vazquez, M. Eugenio; Vogel, Elizabeth M.; Imperiali, Barbara Journal of Organic Chemistry, 2003 , vol. 68, # 17 p. 6795 - 6798
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Citation Number: 49
Abstract
Three 1-(2-nitrophenyl) ethyl-caged phospho-amino acids have been synthesized for use in standard N α-fluorenylmethoxycarbonyl-based solid-phase peptide synthesis (SPPS). The most common naturally occurring phospho-amino acids, serine, threonine, and tyrosine, were prepared as protected caged building blocks by modification with a unique phosphitylating reagent. In previous work, caged phospho-peptides were made using an ...
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