A Metal??Free Multicomponent Cascade Reaction for the Regiospecific Synthesis of 1, 5??Disubstituted 1, 2, 3??Triazoles
G Cheng, X Zeng, J Shen, X Wang…
Index: Cheng, Guolin; Zeng, Xiaobao; Shen, Jinhai; Wang, Xuesong; Cui, Xiuling Angewandte Chemie - International Edition, 2013 , vol. 52, # 50 p. 13265 - 13268 Angew. Chem., 2013
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Citation Number: 44
Abstract
The thermal Huisgen 1, 3-dipolar cycloaddition of organic azides and alkynes to build 1, 2, 3- triazoles usually requires elevated temperatures and provides a mixture of regioisomers.[1] The copper (I)-catalyzed azide–alkyne cycloaddition (CuAAC)[2] and ruthenium (II)- catalyzed azide–alkyne cycloaddition (RuAAC)[3] have been developed as powerful strategies for the regiospecific assembly of 1, 4-disubstituted 1, 2, 3-triazoles and 1, 5- ...
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