Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in …

…, RF Bousley, KL Hamelehle, R Homan…

Index: Lee, Helen T.; Sliskovic, Drago R.; Picard, Joseph A.; Roth, Bruce D.; Wierenga, Wendell; Hicks, James L.; Bousley, Richard F.; Hamelehle, Katherine L.; Homan, Reynold; Speyer, Cecilia; Stanfield, Richard L.; Krause, Brian R. Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5031 - 5034

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Citation Number: 85

Abstract

S0022-2623 (96) 00674-7 CCC: $12.00© 1996 American Chemical Society through the membrane and not the aqueous volume surrounding the membrane. 6 Thus, activity of a membrane-bound inhibitor should depend on both the total inhibitor concentration and the amount of membrane available for inhibitor adsorption. The amount of inhibitor bound to the membrane can be determined at various membrane concentrations from a single ...