Tetrahedron Letters

Synthesis of 5-aryl-3H-[1, 3, 4] oxadiazol-2-ones from N′-(chloro-aryl-methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface …

K Debnath, S Pathak, A Pramanik

Index: Debnath, Kamalesh; Pathak, Sudipta; Pramanik, Animesh Tetrahedron Letters, 2013 , vol. 54, # 8 p. 896 - 899

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Citation Number: 9

Abstract

The synthesis of biologically important 5-aryl-3H-[1, 3, 4] oxadiazol-2-ones has been carried out by heating the easily synthesized N′-(chloro-aryl-methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up ...