Tetrahedron letters

Synthesis of a dihydropyrano [3, 2-e] indole as a rotationally restricted phenolic analog of the neurotransmitter serotonin

JE Macor, ME Newman

Index: Macor; Newman Tetrahedron Letters, 1991 , vol. 32, # 28 p. 3345 - 3348

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Citation Number: 10

Abstract

Abstract 1-(2-Dimethylaminoethyl)-8, 9-dihydropyrano [3, 2-e] indole (1) has been synthesized via a six step procedure involving a Claisen rearrangement of a 5-allyloxyindole- 3-glyoxamide. This novel heterocycle (1) represents a rotationally restricted phenolic analog