Fluorinated tricyclic neuroleptics: synthesis and pharmacology of 2-chloro-8-fluoro-4-(4-methylpiperazino)-4, 5-dihydrothieno [2, 3-b]-1-benzothiepin

Z Polívka, J Holubek, E Svátek…

Index: Polivka; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 9 p. 2222 - 2233

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Citation Number: 5

Abstract

Abstract Diazotization of 4-fluoroanthranilic acid (V) and the following reaction with sodium disulfide gave the dithio diacid VII which was reduced with lithium aluminium hydride to 4- fluoro-2-mercaprobenzyl alcohol (XI). Its reaction with 2-chloro-5-iodothiophene afforded the alcohol XIII which was transformed via the chloride XIV and the nitrile XV to [2-(5-chloro-2- thienylthio)-4-fluorophenyl] acetic acid (XVI). Cyclization with phosphorus pentoxide in ...