Asymmetric reduction of substituted α-and β-ketoesters by Bacillus pumilus Phe-C3
C He, D Chang, J Zhang
Index: He, Chunmao; Chang, Dongliang; Zhang, Jie Tetrahedron Asymmetry, 2008 , vol. 19, # 11 p. 1347 - 1351
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Citation Number: 26
Abstract
The enantioselective reduction of substituted α-and β-ketoesters using resting cells of Bacillus pumilus Phe-C3 was investigated. Effects of substrate concentration on the catalytic efficiency of the microorganism were studied. Preparative scale productions were carried out under the optimized conditions with 62.4–91.0% yields and 90.2–97.1% ee. The cells retained 80% of initial activity after recycling for six times.
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