Examination of acylated 4-aminopiperidine-4-carboxylic acid residues in the phosphotyrosyl+ 1 position of Grb2 SH2 domain-binding tripeptides
…, K Lee, RG Karki, KM Worthy, LK Bindu…
Index: Kang, Sang-Uk; Won, Jun Choi; Oishi, Shinya; Lee, Kyeong; Karki, Rajeshri G.; Worthy, Karen M.; Bindu, Lakshman K.; Nicklaus, Marc C.; Fisher, Robert J.; Burke Jr., Terrence R. Journal of Medicinal Chemistry, 2007 , vol. 50, # 8 p. 1978 - 1982
Full Text: HTML
Citation Number: 7
Abstract
A 4-aminopiperidine-4-carboxylic acid residue was placed in the pTyr+ 1 position of a Grb2 SH2 domain-binding peptide to form a general platform, which was then acylated with a variety of groups to yield a library of compounds designed to explore potential binding interactions, with protein features lying below the βD strand. The highest affinities were obtained using phenylethyl carbamate and phenylbutyrylamide functionalities.
Related Articles:
[Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; Gyoneva, Stefka; Hansen, Kasper B.; Traynelis, Stephen F.; Liotta, Dennis C. Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2334 - 2356]
Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation
[Hishikawa, Kazuhiro; Nakagawa, Hidehiko; Furuta, Toshiaki; Fukuhara, Kiyoshi; Tsumoto, Hiroki; et al. Journal of the American Chemical Society, 2009 , vol. 131, p. 7488 - 7489]
[Maruoka, Hiroshi; Muto, Tsuyoshi; Tanaka, Taisaku; Imajo, Seiichi; Tomimori, Yoshiaki; Fukuda, Yoshiaki; Nakatsuka, Takashi Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3435 - 3439]