Synthesis and preliminary antibacterial evaluation of Linezolid-like 1, 2, 4-oxadiazole derivatives

…, C Cocuzza, CG Fortuna, A Guarcello, P Pierro…

Index: Palumbo Piccionello, Antonio; Musumeci, Rosario; Cocuzza, Clementina; Fortuna, Cosimo Gianluca; Guarcello, Annalisa; Pierro, Paola; Pace, Andrea European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 441 - 448

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Citation Number: 39

Abstract

In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1, 2, 4-oxadiazole ring. Two series of 1, 2, 4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gram-negative bacteria using Linezolid and Ceftriaxone ...