Tetrahedron Letters

Facile synthesis of 4, 5-disubstituted-3 (2H)-pyridazinones

PS Humphries, RM Oliver

Index: Humphries, Paul S.; Oliver, Robert M. Tetrahedron Letters, 2009 , vol. 50, # 22 p. 2682 - 2684

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Citation Number: 7

Abstract

4, 5-Disubstituted-3 (2H)-pyridazinones were initially synthesized via sodium alkoxide additions to an advanced bromide intermediate. A small parallel chemistry effort resulted in a poor success rate, and we thus increased the reactivity of the reaction partner by performing a copper-catalyzed Finkelstein reaction. Copper-catalyzed coupling of a diverse set of alcohols with the resulting iodide resulted in a more successful effort. A number of ...