Facile and practical synthesis of 2, 6-dichloropurine
…, B Huang, K Danielsen, R Shukla…
Index: Zeng, Qi; Huang, Bangzhou; Danielsen, Knut; Shukla, Rajesh; Nagy, Thomas Organic Process Research and Development, 2004 , vol. 8, # 6 p. 962 - 963
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Citation Number: 10
Abstract
2,6-Dichloropurine is an important pharmaceutical intermediate. 1 It has been widely used in the preparation of purine nucleosides and purine nucleotides. 2 There are mainly two routes for the preparation of 2,6-dichloropurine. The first route is by chlorinating the purine ring structure, for example chlorinating xanthine (2,6-dihydroxypurine) with pyrophosphoryl chloride in a sealed tube at high temperature 3 or with phosphorus oxychloride at reflux in the ...
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