Design, synthesis and biological evaluation of 1, 3-diaminopropanes: a new class of polyamine analogs as leishmanicidal agents

VV Kumar, SK Singh, AP Bhaduri, S Gupta…

Index: Kumar, Versha Vinay; Singh, Sudhir K.; Sharma; Bhaduri; Gupta, Suman; Zaidi, Alima; Tiwari, Suman; Katiyar Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 675 - 680

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Citation Number: 7

Abstract

Analogs of 1, 3-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated for their antileishmanial activity. Of the many active compounds, 1-(3-N, N-bis methoxycarbonyl guanidino) propyl-4-methylpiperidine piperazine (4ef) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration.