Enantioselective Preparation of 2, 4??Disubstituted Azetidines

A Marinetti, P Hubert, JP Genêt

Index: Marinetti, Angela; Hubert, Philippe; Genet, Jean-Pierre European Journal of Organic Chemistry, 2000 , # 9 p. 1815 - 1820

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Citation Number: 3

Abstract

Abstract Chiral C 2-symmetric N-benzylazetidines have been conveniently prepared from optically pure anti-1, 3-diols without loss of enantiomeric purity. N-Debenzylation led to the corresponding N-unsubstituted azetidines, which were then subjected to palladium- catalysed coupling reactions with aryl bromides to afford chiral N-arylazetidines.(R, R)-N- Benzyl-2, 4-dimethylazetidine has been employed in the synthesis of a new ...