Bioactive 4-substituted-6-methyl-2-pyrones with promising cytotoxicity against A2780 and K562 cell lines

LR Marrison, JM Dickinson, IJS Fairlamb

Index: Marrison, Lester R; Dickinson, Julia M; Fairlamb, Ian J S Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3509 - 3513

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Citation Number: 66

Abstract

Bioactive synthetic 4-substituted-6-methyl-2-pyrones are reported. Various 4-substitutents have been incorporated using Pd-catalysed carbon–carbon bond coupling procedures. Preliminary screening of the 2-pyrones against human ovarian carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines show that 4-alkynyl-6-methyl-2- pyrones have excellent potential as anticancer agents. The pyrones demonstrate broad ...