Advanced synthesis & catalysis

Aerobic Oxidative Coupling of o??Xylene: Discovery of 2??Fluoropyridine as a Ligand to Support Selective Pd??Catalyzed C H Functionalization

Y Izawa, SS Stahl

Index: Izawa, Yusuke; Stahl, Shannon S. Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3223 - 3229

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Citation Number: 43

Abstract

Abstract An improved method for the direct oxidative coupling of o-xylene could provide streamlined access to an important monomer used in polyimide resins. The use of 2- fluoropyridine as a ligand has been found to enable unprecedented levels of chemo-and regioselectivity in this palladium-catalyzed aerobic oxidative coupling reaction. Preliminary insights have been obtained into the origin of the effectiveness of 2-fluoropyridine as a ...