Synthesis

Efficient Preparation of Polyfunctional Indoles via a Zinc Organometallic Variation of the Fischer Indole Synthesis

ZG Zhang, BA Haag, JS Li, P Knochel

Index: Zhang, Zhi-Guang; Haag, Benjamin A.; Li, Jin-Shan; Knochel, Paul Synthesis, 2011 , # 1 p. 23 - 29

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Citation Number: 6

Abstract

Abstract Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up.