Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution

CA Blum, X Zheng, H Brielmann, KJ Hodgetts…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4573 - 4577

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Citation Number: 21

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Activation of TRPV1 on sensory neurons by chemical stimulants, including capsaicin and resiniferatoxin, as well as low pH and heat, leads to an influx of calcium and sodium ions through the channel, causing depolarization of the cell ...