Synthesis and Biological Activities of 2??Amino??thiazole??5??carboxylic Acid Phenylamide Derivatives

…, H Qian, W Huang, X Cai, P Cao, A Wellner…

Index: Liu, Wukun; Zhou, Jinpei; Qi, Fan; Bensdorf, Kerstin; Li, Zhiyu; Zhang, Huibin; Qian, Hai; Huang, Wenlong; Cai, Xueting; Cao, Peng; Wellner, Anja; Gust, Ronald Archiv der Pharmazie, 2011 , vol. 344, # 7 p. 451 - 458

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Citation Number: 12

Abstract

Abstract In an attempt to develop potent and selective anti-tumor drugs, a series of novel 2- amino-thiazole-5-carboxylic acid phenylamide derivatives were designed based on the structure of dasatinib. All compounds were synthesized by a systematic combinatorial chemical approach. Biological evaluation revealed that N-(2-chloro-6-methylphenyl)-2-(2-(4- methylpiperazin-1-yl) acetamido) thiazole-5-carboxamide (6d) exhibited high ...