Photoactivation of (p??Methoxyphenyl)(trifluoromethyl) diazirine in the Presence of Phenolic Reaction Partners

B Raimer, T Lindel

Index: Raimer, Bjoern; Lindel, Thomas Chemistry - A European Journal, 2013 , vol. 19, # 21 p. 6551 - 6555

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Citation Number: 9

Abstract

Diazirines are of key importance for photoaffinity labeling (PAL), a technique used for covalently linking noncovalently binding molecules in a bioorthogonal manner by irradiation at about 360 nm.[1, 2] After separation and identification, the covalent adducts are to be analyzed by mass spectrometry. From a chemist s perspective, the products formed on photolabeling of biomolecules should be known as exactly as possible. However, studies ...