Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase

…, J Parkes, R Raymond, J Nobrega, S Houle…

Index: Sadovski, Oleg; Hicks, Justin W.; Parkes, Jun; Raymond, Roger; Nobrega, Jose; Houle, Sylvain; Cipriano, Mariateresa; Fowler, Christopher J.; Vasdev, Neil; Wilson, Alan A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4351 - 4357

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Citation Number: 16

Abstract

Fatty acid amide hydrolase (FAAH), the enzyme responsible for terminating signaling by the endocannabinoid anandamide, plays an important role in the endocannabinoid system, and FAAH inhibitors are attractive drugs for pain, addiction, and neurological disorders. The synthesis, radiosynthesis, and evaluation, in vitro and ex vivo in rat, of an 18F-radiotracer designed to image FAAH using positron emission tomography (PET) is described. ...