Lewis Acid??Catalyzed Selective Synthesis of Diversely Substituted Indolo??and Pyrrolo [1, 2??a] quinoxalines and Quinoxalinones by Modified Pictet–Spengler …

…, T Aggarwal, RP Singh, R Chandra

Index: Verma, Akhilesh K.; Jha, Rajeev R.; Sankar, V. Kasi; Aggarwal, Trapti; Singh, Rajendra P.; Chandra, Ramesh European Journal of Organic Chemistry, 2011 , # 34 p. 6998 - 7010

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Citation Number: 27

Abstract

Abstract An efficient tandem process for the selective synthesis of 1, 2-annulated α-fused quinoxalines using benzotriazole methodology by a modified Pictet–Spengler reaction is described. The approach involves the reaction of arylamines 4 with aromatic aldehydes 5 to furnish 6-endo-dig-cyclized products. Dihydroquinoxalines 6 were selectively obtained by using AlCl 3 in tetrahydrofuran (THF) at room temperature for two hours. However, after ...