Synthesis of Aminopyrazoles from α-Oxoketene O, N-Acetals Using Montmorillonite K-10/Ultrasound
…, DM Henriques, L de Carvalho Tavares
Index: Braibante, Mara E. F.; Braibante, Hugo T. S.; Da Roza, Juliano K.; Henriques, Danielle M.; De Carvalho Tavares, Luciana Synthesis, 2003 , # 8 p. 1160 - 1162
Full Text: HTML
Citation Number: 12
Abstract
The procedure for the condensation of the primary amines with β-oxothioxo esters for the synthesis of α-oxoketene O,N-acetals has been reported in the literature. [17] The regiochemistry of these reactions shows strong dependence on the reaction medium and reaction conditions. When the reaction is carried out with formic acid under reflux in toluene, β-oxothioxo esters are obtained. Without formic acid, a mixture of α-oxoketene O,N-acetals and enaminothio ...
Related Articles:
Microwave-Assisted Ullmann C− S Bond Formation: Synthesis of the P38α MAPK Clinical Candidate VX-745
[Bagley, Mark C.; Davis, Terence; Dix, Matthew C.; Widdowson, Caroline S.; Kipling, David Organic and Biomolecular Chemistry, 2006 , vol. 4, # 22 p. 4158 - 4164]
[Bioorganic and Medicinal Chemistry, , vol. 14, # 22 p. 7501 - 7511]
Synthesis of Aminopyrazoles from α-Oxoketene O, N-Acetals Using Montmorillonite K-10/Ultrasound
[Synthesis, , # 8 p. 1160 - 1162]
Synthesis of Aminopyrazoles from α-Oxoketene O, N-Acetals Using Montmorillonite K-10/Ultrasound
[Synthesis, , # 8 p. 1160 - 1162]
[European Journal of Medicinal Chemistry, , vol. 78, p. 294 - 303]