N-[2-[4-(4-Chlorophenyl) piperazin-1-yl] ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand

…, NA Colabufo, M Leopoldo, V Tortorella

Index: Perrone; Berardi; Colabufo; Leopoldo; Tortorella Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4903 - 4909

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Citation Number: 24

Abstract

A series of new 1-aryl-4-alkylpiperazines containing a terminal benzamide fragment or a tetralin-1-yl nucleus on the alkyl chain were synthesized and tested for binding at cloned human dopamine D4 and D2 receptor subtypes. A SAFIR (structure-affinity relationship) study on this series is herein discussed. The most relevant D4 receptor affinities were displayed by N-[ω-[4-arylpiperazin-1-yl] alkyl]-methoxybenzamides (compounds 5, 16-20), ...