Total syntheses of cyanthiwigins B, F, and G

JA Enquist, SC Virgil, BM Stoltz

Index: Enquist Jr., John A.; Virgil, Scott C.; Stoltz, Brian M. Chemistry - A European Journal, 2011 , vol. 17, # 36 p. 9957 - 9969

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Citation Number: 27

Abstract

Abstract A concise and versatile approach toward the preparation of the cyanthiwigin family of cyathane natural products is described. By leveraging a unique double asymmetric catalytic alkylation procedure it is possible to quickly establish two of the most critical stereocenters of the cyanthiwigin framework with high levels of selectivity and expediency. The synthetic route additionally employs both a tandem ring-closing cross-metathesis ...