Tetrahedron letters

Tandem amine propargylation-Sonogashira reactions: new three-component coupling leading to functionalized substituted propargylic amines

N Olivi, P Spruyt, JF Peyrat, M Alami, JD Brion

Index: Alami, Mouad; Peyrat, Jean-Francois; Brion, Jean-Daniel Tetrahedron Letters, 2002 , vol. 43, # 16 p. 3007 - 3009

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Citation Number: 39

Abstract

Three-component coupling reactions of propargyl halides, amines, and organic halides in the presence of palladium–copper catalysis produced efficiently highly functionalized propargylic amines in good to excellent yields at room temperature. Extension to the