New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity

C Le Sann, A Baron, J Mann, H van den Berg…

Index: Le Sann, Christine; Baron, Anne; Mann, John; Van Den Berg, Hendrik; Gunaratnam, Mekala; Neidle, Stephen Organic and Biomolecular Chemistry, 2006 , vol. 4, # 7 p. 1305 - 1312

Full Text: HTML

Citation Number: 41

Abstract

We describe new methodology for the synthesis of symmetric bis-benzimidazoles carrying 2- aryl moieties, including 2-[4-(3′-aminopropoxy) phenyl] and 2-[4-(3′-aminopropanamido) phenyl] substituents, together with the synthesis of novel hybrid molecules comprising bis- benzimidazoles in ester and amide combination with the N-mustard chlorambucil. The in vitro activities of these compounds against five cancer cell lines are also provided.