Benzo [f] naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens

…, S Wentzler, JL Malleron, S Dutka-Malen…

Index: Tabart, Michel; Picaut, Guy; Lavergne, Marc; Wentzler, Sylvie; Malleron, Jean-Luc; Dutka-Malen, Sylvie; Berthaud, Nadine Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1329 - 1331

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Citation Number: 10

Abstract

The synthesis and antibacterial activity of benzo [f][1, 7] naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use.