Facile construction of 3-hydroxyphenanthrene-1, 4-diones: key intermediates to tanshinone I and its A-ring-modified analogue
M Jiao, C Ding, A Zhang
Index: Jiao, Mingkun; Ding, Chunyong; Zhang, Ao Tetrahedron, 2014 , vol. 70, # 18 p. 2976 - 2981
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Citation Number: 3
Abstract
Abstract A mild synthetic approach was established allowing for a convenient construction of tricyclic hydroxyphenanthraquinones, the key precursor for total synthesis of tanshinone I. This tandem process includes decarboxylative radical alkylation, intramolecular C–H arylation and one-pot O-demethylation and aromatization. Variously substituted phenylpropanoic acids were well tolerated in this approach, and synthesis of tanshinone I ...
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