Selective Hydrolysis of 2, 4-Diaminopyrimidine Systems: A Theoretical and Experimental Insight into an Old Rule

…, JL Matallana, JL Falcó, B Martinez-Teipel

Index: Teixido; Borrell; Colominas; Deupi; Matallana; Falco; Martinez-Teipel Journal of Organic Chemistry, 2001 , vol. 66, # 1 p. 192 - 199

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Citation Number: 3

Abstract

Hydrolysis of the amino groups in condensed 2, 4-diaminopyrimidine systems (1) has been used as a common method for the synthesis of oxo-substituted pyrimidines. In particular, the treatment with 6 M HCl usually yields exclusively the 2-amino-4-oxopyrimidine isomer (2). During our work, we found that the hydrolysis of the amino groups present in some condensed 2, 4-diaminopyrimidine systems unexpectedly afforded exclusively the 4- ...