The first Bischler–Napieralski cyclization in a room temperature ionic liquid
ZMA Judeh, CB Ching, J Bu, A McCluskey
Index: Judeh, Zaher M.A.; Ching, Chi Bun; Bu, Jie; McCluskey, Adam Tetrahedron Letters, 2002 , vol. 43, # 29 p. 5089 - 5091
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Citation Number: 56
Abstract
We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3- methylimidazoliumhexafluorophosphate ([bmim] PF6), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler–Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated.
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