Formation of α??Hydroxy?螃漫?diketones through Hydroxylation of Isoxazolium Salts: Stereoselective Approach to Angular cis??Diols in Polycyclic Systems

H Takikawa, A Takada, K Hikita…

Index: Takikawa, Hiroshi; Takada, Akiomi; Hikita, Katsuyoshi; Suzuki, Keisuke Angewandte Chemie - International Edition, 2008 , vol. 47, # 39 p. 7446 - 7449

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Citation Number: 22

Abstract

Among the natural products of the type-II polyketide biosynthesis,[1] highly oxidized polycyclic structures, such as auxarthrol B (1)[2] and tetracenomycin C (2),[3] are attractive for their biological relevance as well as for synthetic challenges (Scheme 1). In our continuing synthetic studies on the exploitation of isoxazole-based intermediates like A,[4] we have addressed the issue of installing the “angular cisdiols” that are characteristic of ...