2-Amino-2-oxazolin-4-ones. I. Synthesis1a

CF Howell, NQ Quinones…

Index: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

Full Text: HTML

Citation Number: 13

Abstract

A series of new 5-aryl-2-dialkylamino-2-oxazolin-4ones has been prepared by (a) condensation of mandelic acid derivatives with dialkylcyanamides (b) aminolysis or (c) alkylation of 2-amino-S-aryl-2-oxa~ olin4ones1 and (d) aminolysis of 5-aryl-2-thio-2.4 oxazolidinediones with secondary amines. Pharmacological results indicate that 2dimethylamino-5-phenyl-2-oxazolin-4one (II) Ib is particularly interesting aa a mild ...