Tetrahedron Letters

A convenient and expeditious synthesis of 3-(N-substituted) aminocoumarins via palladium-catalyzed Buchwald–Hartwig coupling reaction

D Audisio, S Messaoudi, JF Peyrat, JD Brion, M Alami

Index: Audisio, Davide; Messaoudi, Samir; Peyrat, Jean-Francois; Brion, Jean-Daniel; Alami, Mouad Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6928 - 6932

Full Text: HTML

Citation Number: 64

Abstract

A convenient protocol for the rapid and efficient synthesis of 3-(N-substituted) aminocoumarins is described. The synthetic route developed involves the Pd-catalyzed C–N coupling reaction from readily available 3-bromocoumarin derivatives in the presence of the catalytic system Pd (OAc) 2/Xantphos. Under these conditions, a series of nucleophiles including amides, sulfonamides, carbamates and functionalized amines, have been ...