Combinatorial synthesis of 3, 5-dimethylene substituted 1, 2, 4-triazoles

SS Woodard, KD Jerome

Index: Woodard, Scott S.; Jerome, Kevin D. Combinatorial Chemistry and High Throughput Screening, 2011 , vol. 14, # 2 p. 132 - 137

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Citation Number: 5

Abstract

Abstract: Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. ... Keywords: Cyclizations, combinatorial chemistry, 1,2,4-triazoles, Pinner reaction, hydrazides, imidates. ... Substituted 1,2,4-triazoles [1] have become very important in medicinal chemistry due to their ability to display a high ...