Total synthesis of cryptophycin 3

P Danner, M Bauer, P Phukan…

Index: Danner, Paulami; Bauer, Matthias; Phukan, Prodeep; Maier, Martin E. European Journal of Organic Chemistry, 2005 , # 2 p. 317 - 325

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Citation Number: 18

Abstract

Abstract The depsipeptide cryptophycin 3 (5) and the cryptophycin analogue 43 were prepared from the corresponding four subunits. The tripeptide analogue 34 was acquired from the starting amino ester 33, which contains fragments D and C. After extension at the carboxyl function by esterification with the hydroxy ester 10, the seco compounds 37 and 42 were obtained. Ring closure was achieved by macrolactamization in the presence of ...

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