An Improved Preparation of N 2??tert??Butoxycarbonyl??and N 2??Benzyloxy??carbonyl??(S)??2, 4??diaminobutanoic Acids
R Andruszkiewicz, D Rożkiewicz
Index: Andruszkiewicz, Ryszard; Rozkiewicz, Dorota Synthetic Communications, 2004 , vol. 34, # 6 p. 1049 - 1056
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Citation Number: 10
Abstract
Abstract Utilizing N??benzyloxycarbonyl??(1a) and N??tert??butoxycarbonyl??(S)??glutamine (1b), a highly efficient and practical method for the synthesis of N 2??benzyloxycarbonyl??and N 2?? tert??butoxycarbonyl??(S)??2, 4??diaminobutanoic acids (2a and 2b) has been developed. Reaction of (S)??glutamine derivatives with iodosobenzene diacetate in a mixture of THF?? water at 4° C afforded selectively protected (S)??2, 4??diaminobutanoic acids in good yields.
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