Nitrosyl cyanide, a putative metabolic oxidation product of the alcohol-deterrent agent cyanamide

…, DJW Goon, EG DeMaster, HT Nagasawa

Index: Shirota, Frances N.; Goon, David J.W.; DeMaster, Eugene G.; Nagasawa, Herbert T. Biochemical Pharmacology, 1996 , vol. 52, # 1 p. 141 - 147

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Citation Number: 20

Abstract

When incubated with catalase/glucose-glucose oxidase, 13C-labeled cyanamide gave rise not only to 13C-labeled cyanide, but also to 13C-labeled CO2. Moreover, a time-dependent formation of nitrite was observed when cyanamide was oxidized in this system. These results suggested that the initial product of cyanamide oxidation, viz. N-hydroxycyanamide, was being further oxidized by catalase/H2O2 to nitrosyl cyanide (O N C N). ...