(Acylaryloxy) acetic acid diuretics. 3. 2, 3-Dihydro-5-acyl-2-benzofurancarboxylic acids, a new class of uricosuric diuretics

…, FC Novello, EJ Cragoe Jr, JP Springer…

Index: Hoffman, William F.; Woltersdorf, Otto W.; Novello, Frederick C.; Cragoe, Edward J; Spinger, James P.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 7 p. 865 - 873

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Citation Number: 32

Abstract

Other carboxyl derivatives include the hydrazide 17 and guanidide 18, which were prepared by the reaction of the ester llb with hydrazine and guanidine, respectively (Scheme V). To study the effect of carboxy surrogates, the tetrazole 21 was prepared by the reaction sequence shown in Scheme VI. The carbonyl moiety was replaced with a sulfonyl group by treating 9 with 2-thiophenesulfonyl chloride under Friedel-Crafts conditions to give 22 as ...