Synthesis and Preliminary Pharmacology of an Internal Standard for Assay of Neostigmine

…, JJ Freeman, JW Kosh, JW Sowell

Index: Ward Jr.; Freeman; Sowell; Kosh Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 4 p. 433 - 435

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Citation Number: 3

Abstract

Abstract The synthesis of the diethyl analog of neostigmine, its preliminary pharmacology, and its use as an internal standard for the GLC assay of neostigmine are described. Both the diethyl analog and neostigmine undergo thermal demethylation in the injection port. The column selected produced satisfactory resolution and short retention times for neostigmine and the diethyl analog. The diethyl analog apparently possesses acetylcholinesterase- ...