Russian Journal of Organic Chemistry

Synthesis of epothilone D with the forced application of oxycyclopropane intermediates

AL Hurski, OG Kulinkovich

Index: Hurski; Kulinkovich Russian Journal of Organic Chemistry, 2011 ,  vol. 47,  # 11  p. 1653 - 1674

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Citation Number: 9

Abstract

Abstract The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation—opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C 7–C 12 and C 13–C 21 in the target molecule.