Tetrahedron

Synthesis of 2, 2-dialkylcyclopropylamines from β-chloroimines and application towards the synthesis of1-amino-2, 2-dialkylcyclopropane-carboxylic acids

N De Kimpe, P Sulmon, M Boeykens

Index: De Kimpe; Sulmon; Boeykens Tetrahedron, 1991 ,  vol. 47,  # 20-21  p. 3389 - 3406

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Citation Number: 11

Abstract

Base-induced 1, 5-dehydrochlorination of β-chloroimines, having a relatively acidic hydrogen atom at carbon-1 of the N-substituent (eg benzyl, methoxycarbonylmethyl, α- methylbenzyl), afforded N-cyclopropylimines which were easily hydrolyzed into