Chemistry Letters

Highly enantioselective aldol reaction of methyl ketones via chiral stannous azaenolates

K Narasaka, T Miwa, H Hayashi, M Ohta

Index: Narasaka, Koichi; Miwa, Tetsuo; Hayashi, Hiroki; Ohta, Masako Chemistry Letters, 1984 , p. 1399 - 1402

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Citation Number: 13

Abstract

Chiral 1, 3-oxazolidines are readily prepared from methyl ketones and chiral norephedrine. Formation of stannous azaenolates from the oxazolidines and reaction with aldehydes followed by removal of the chiral auxiliary lead to the aldol products in high level of enantiomeric purity.