A solid-phase approach to novel purine and nucleoside analogs

J Chang, C Dong, X Guo, W Hu, S Cheng…

Index: Chang, Junbiao; Dong, Chunhong; Guo, Xiaohe; Hu, Weidong; Cheng, Senxiang; Wang, Qiang; Chen, Rongfeng Bioorganic and Medicinal Chemistry, 2005 ,  vol. 13,  # 15  p. 4760 - 4766

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Citation Number: 13

Abstract

This paper describes a method for the preparation of purine analogs using the solid-phase approach. Nucleoside bases were constructed on Merrifield resin by sequential displacement of purine dichloride with amines, and after detachment, the purine analogs were condensed with d, l-ribofuranoside compounds by the Vorbrüggen method. Thereof, l- ribofuranoside was prepared from l-arabinose via the selective oxidation–reduction ...